Revista Portuguesa de Pneumologia Revista Portuguesa de Pneumologia
Rev Port Pneumol 2017;23:273-9 - Vol. 23 Num.5 DOI: 10.1016/j.rppnen.2017.04.003
Original article
Effects of exposure to biomass burning on pulmonary inflammatory markers and pulmonary function in individuals with COPD
D. Ramosa,, , M. Proençab, M.R. Leitec, A.D. Ferreiraa,d, I.B. Trevisana, G.F.S. Brígidaa, G.Y. Tacaoa, E.M.C. Ramosa
a Department of Physiotherapy, São Paulo State University (UNESP), Presidente Prudente, São Paulo, Brazil
b Department of Physiotherapy, State University of North of Parana (UENP), Jacarezinho, Paraná, Brazil
c Pulmonary Division, Heart Institute, University of São Paulo Medical School, São Paulo, Brazil
d Department of Physiotherapy, The University of Western São Paulo, Presidente Prudente, São Paulo, Brazil
Received 22 December 2016, Accepted 02 April 2017
Abstract
Introduction

Pulmonary rehabilitation (PR) has many benefits for individuals with COPD. However, it is not clear whether PR could prevent the hazards of air pollution exposure. This study aimed to analyze the effects of biomass burning exposure on pulmonary inflammatory markers and pulmonary function in individuals with COPD, participants and non-participants of PR.

Methods

35 subjects were divided into three groups: individuals with COPD who received PR (G1, n=15), those who did not (G2, n=10), and a control group composed of healthy individuals without COPD (CG, n=10). Measurements of lung function and concentrations of IL-6, IL-10, and TNF-α in exhaled breath condensate samples were collected. The assessment and concentrations of particulate matter (PM10), nitrogen dioxide (NO2), ozone (O3), temperature (T), and relative air humidity (RAH) were recorded in biomass burning and non-burning periods.

Results

There was a significant increase in the concentrations of air pollutants in the biomass burning period. In this period, an increase in IL-6 (G1p=0.041, G2 p=.012), and a reduction in the FEV1/FVC ratio (G1p=0.021, G2 p=.007) were observed in individuals with COPD. In G1, the increase in IL-6 concentrations correlated positively with O3 (r=0.693; p=.006), and negatively with RAH (r=−0.773; p=.003) in the burning period.

Conclusions

Individuals with COPD exposed to biomass burning demonstrated increased pulmonary inflammation and a reduction in the FEV1/FVC ratio, regardless of their engagement in PR.

Keywords
COPD, Air pollution, Pulmonary inflammatory markers, Lung, Interleukins, Spirometry
Rev Port Pneumol 2017;23:273-9 - Vol. 23 Num.5 DOI: 10.1016/j.rppnen.2017.04.003